COLLABORATIVE LONGITUDINAL EVALUATION
OF ETHNICITY AND REFRACTIVE ERROR
(CLEERE) STUDY

Purpose

		To compare and contrast normal eye growth, ocular component development, and refractive error development in Native American, Hispanic, African-American, Asian, and Caucasian schoolchildren.
		To investigate risk factors for the development of myopia.

Background

The Orinda Longitudinal Study of Myopia (OLSM) was started in 1989 to investigate normal eye growth and the development of myopia in over 1,200 school-aged children to date. Phase 1 investigates additional factors that may predict the onset of juvenile myopia (accommodative function, peripheral refractive error, intraocular pressure, and school achievement). Phase 2 (CLEERE) compares and contrasts the optical ocular components and refractive error profiles of several ethnic groups.

Description

The CLEERE Study is a multi-center, observational investigation of ocular development and refractive error development in schoolchildren. It adds three clinical centers to the Orinda Longitudinal Study of Myopia (OLSM), begun in 1989, specifically to describe normal ocular growth in children ages 6 to 14 years, and to develop the ability to predict juvenile onset myopia before it is clinically evident. In addition to the more than 1,300 predominantly Caucasian children enrolled in the OLSM, four additional clinical sites enroll Native American, African-American, Hispanic, and Asian children. The children are examined annually for at least four years. Examinations include visual acuity, refraction by a variety of methods (cycloplegic autorefraction being the primary outcome measure), cover test at distance and near, accommodative response assessment with the autorefractor, response AC/A ratio measurement, videophakometry, peripheral refraction, and A-scan ultrasonography.

Drops and Assessment with an Autorefractor